The post of yours I quoted said popularity shouldn't be a qualification to headlining a music venue. So if you do mean headlining a music venue then the answer is obviously yes.
If you mean headline Glastonbury, then it's a question of their style of music not popularity. The headliners of Glastonbury have always been, above all else, popular.
I don't know if you've ever done gig promotion, but I have. Like lots of others, I started by thinking I'd be different, it would get successful because of quality music not number of punters. I very quickly realised that this was the way to lose money.