A lot will depend on how the EU reacts to the leave decision. Will they play hard-ball with us to "teach us a lesson" and deter other countries who might be contemplating doing the same? On the other hand they now know we are serious and getting out asap which will mean a huge hole in their income (ok, not right away) and a possible threat to their exports to us if they start a tariff war.
I am old enough to remember the Common Market and that seemed to work pretty well. The political union was when the rot started to set in and the money-gobbling bureaucratic monster was born. Interesting times ahead.