So a contribution from someone who would have a vote...

Brexit has been a gamechanger. We are told that the only way to stay in the EU was to say no to independence. Well that worked out well, didn't it. We feel shafted.
What is also changes, to a degree, the economic argument. If Scotland were in the EU as an independent country, we would be the natural home for Financial Services and Logistics companies that are based in England but need an EU base - English speaking, good schools, same time zone - it's a no brainer. I expect that we would still lose out financially, but this narrows the gap.
What has also changed is the perception of England - right wing and narrow minded, whereas Scotland sees itself as Social Democrat and open to the world. We are on different paths, and this has become increasingly apparent since the last independence referendum.
And finally, you cannot begin to imagine just how much Boris Johnson is loathed up here.