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Ian Gough.
Regarding the pfizer vaccines, can anyone explain what it meant by this: "The Pfizer and BioNTech covid-19 vaccine may provide some early protection, starting 12 days after the first dose, the peer reviewed results of a phase III trial have found.
The study, published in the New England Journal of Medicine,1 found that vaccine efficacy between the first and second doses was 52% (95% credible interval 29.5% to 68.4%)."
(https://www.bmj.com/content/371/bmj.m4826 posting source because I don't know if there is more up-to-date information).
It's obviously an incredibly difficult decision to make regarding how to roll-out vaccines with speed of highest importance for vulnerable people, and some protection much better than none at all.
Not quite sure what those stats refer too, I thought it was 91% after the first jab, hence Tony Bliar saying why bother with 2nd jab as it’s only another 4%? Think the 2nd will give it longevity maybe? But you can wait 12 weeks so get more people done with first one asap which makes sense.
Yes I realise that the medical standards people wouldn't agree to the 12c week wait just for political reasons, so it must be a science and knowledge based decision.
What does bother me is that if they use all the doses for first jabs then eventually they will have to stop giving first jabs for 12 weeks while all those people get their second jab. That's not science or political it is simple supply and demand
It's saying that after the first dose 52% of people had some protection...this ranged from 29.5% to 68.4% in various trials. The second dose given within 3 weeks lifted the protection rate to 95%. Pfizer have no evidence of effectiveness using the regime the UK proposes which is the second dose within 12 weeks. Dr Chris Whitty says the first injection gives the biggest response the second dose being a booster. He is right but it's marginal...ie 52% protection first dose increasing by another 43% after the second dose.
The MHRA approved the drug based on the Pfizer data and they in turn have said that this was on a regime of a repeat dose within 3 weeks. Looks like in our panic to get this vaccination out asap they are willing to accept that up to half the people having it will not be protected until they get the second dose and there is no evidence that the second dose will be as effective given at 12 weeks compared to the Pfizer recommended regime of repeat in 3 weeks..
The above may not be relevant for the AZ vaccine as I've not looked at the data they have published or the dose regime used
In my opinion this sudden and cavalier change from UK chief medical officers without any scientific evidence risks messing up the whole bloody thing. Have any countries followed our lead....no way!
You don't expect him to reveal his 'sauces' do you?
But when a doctor or whoever from some hospital or university or whatever comes on the TV or in the papers and casts doom and gloom I alwyas wonder how many the news outlet spoke to before they found one who would say what they wanted.
After all, as we know, bad news is good news for journalists.