Coronavirus update - NO MORE RESTRICTIONS

[lisvaneblue]

Re: Coronavirus update

https://www.theguardian.com/world/20...zeneca-vaccine

Now that the trial details are in the public domain I doubt the US FDA will approve it until further trails are done in elderly patients. I guess the UK MHRA might approve it for use in those under 55, but not the elderly based on current data.

[Hilts]

Re: Coronavirus update

Still reckon the Oxford will be first rolled out to the vulnerable.

Pubs shut again from Tuesday I reckon.

[Delbert]

Re: Coronavirus update

The claim made by AstraZeneca / Oxford that the vaccine has 70% efficacy seems hard to justify given that figure was achieved by combining the results of 2 different dosing regimes one of which was a small subset containing no over 55s (90%) and the other a larger group which did contain over 55s (62%).

Surely the correct headline should be the vaccine has 62% efficacy but that further studies are to be carried out on a large representative population to see if the half dose then full dose regime does have greater efficacy.

Given the enormous political capital invested in this vaccine by the UK Government I wonder whether this has had the effect of pressurising AstraZeneca / Oxford to make a claim which at this point in time, according to some independent scientific opinion, does not appear to stand up to close scrutiny? A headline of 62% efficacy would not have looked great compared to the 95% efficacy claimed by the other 2 vaccines.

[the other bob wilson]

Re: Coronavirus update

The claim made by AstraZeneca / Oxford that the vaccine has 70% efficacy seems hard to justify given that figure was achieved by combining the results of 2 different dosing regimes one of which was a small subset containing no over 55s (90%) and the other a larger group which did contain over 55s (62%).

Surely the correct headline should be the vaccine has 62% efficacy but that further studies are to be carried out on a large representative population to see if the half dose then full dose regime does have greater efficacy.

Given the enormous political capital invested in this vaccine by the UK Government I wonder whether this has had the effect of pressurising AstraZeneca / Oxford to make a claim which at this point in time, according to some independent scientific opinion, does not appear to stand up to close scrutiny? A headline of 62% efficacy would not have looked great compared to the 95% efficacy claimed by the other 2 vaccines.

And yet flu vaccines have 60% efficacy apparently, so while I can understand the need for further testing of the 90% claim on older people, it seems that the Oxford vaccine falls within standards which have been accepted for other vaccines.

[Rjk]

Re: Coronavirus update

And yet flu vaccines have 60% efficacy apparently, so while I can understand the need for further testing of the 90% claim on older people, it seems that the Oxford vaccine falls within standards which have been accepted for other vaccines.

if they're effectively cherry picking results to appear better the. really we don't know what the efficacy is.

[xsnaggle]

Re: Coronavirus update

if they're effectively cherry picking results to appear better the. really we don't know what the efficacy is.

From what I've read it was all blown out of proportion by 1 (one) journo opining bthat the US drug agency probably wouldn't approve it.
Lets be fair, do we care if they do or not if it works.
It is far better suited to treating the poor of the world than something that needs -70C to survive.
The USA can do waht they like!

[the other bob wilson]

Re: Coronavirus update

if they're effectively cherry picking results to appear better the. really we don't know what the efficacy is.

Efficacy has been put at 62% and I've not come across anyone directly contesting that figure yet, the issue is with whether the 90% claim extends to over 55s and, for the moment, there's no way of knowing that.

[Gofer Blue]

Re: Coronavirus update

It is unfortunate that the half dose followed by a full dose regimen turned out to be the result of a mistake, even if it was serendipity that it seems to be more efficient than two full doses! For me that immediately casts doubt over the whole trial which is a shame. If they will now have to repeat a full scale Phase 3 study with more elderly volunteers included then that is going to cause quite a delay.

Obviously the Yanks will make a meal of this as they are the greatest/best at everything.

[goats]

Re: Coronavirus update

The claim made by AstraZeneca / Oxford that the vaccine has 70% efficacy seems hard to justify given that figure was achieved by combining the results of 2 different dosing regimes one of which was a small subset containing no over 55s (90%) and the other a larger group which did contain over 55s (62%).

Surely the correct headline should be the vaccine has 62% efficacy but that further studies are to be carried out on a large representative population to see if the half dose then full dose regime does have greater efficacy.

Given the enormous political capital invested in this vaccine by the UK Government I wonder whether this has had the effect of pressurising AstraZeneca / Oxford to make a claim which at this point in time, according to some independent scientific opinion, does not appear to stand up to close scrutiny? A headline of 62% efficacy would not have looked great compared to the 95% efficacy claimed by the other 2 vaccines.

You believe want the yanks are saying? They desperately want there £20 a shot one to be the one the world wants, at less than a fifth of the cost the Oxford one presents a massive threat to that. If they can achieve 90% with a lesser dose also then happy days.....

[goats]

Re: Coronavirus update

It is unfortunate that the half dose followed by a full dose regimen turned out to be the result of a mistake, even if it was serendipity that it seems to be more efficient than two full doses! For me that immediately casts doubt over the whole trial which is a shame. If they will now have to repeat a full scale Phase 3 study with more elderly volunteers included then that is going to cause quite a delay.

Obviously the Yanks will make a meal of this as they are the greatest/best at everything.

Was the half dose a mistake? I thought it was part of the trial?

[Croesy Blue]

Re: Coronavirus update

You believe want the yanks are saying? They desperately want there £20 a shot one to be the one the world wants, at less than a fifth of the cost the Oxford one presents a massive threat to that. If they can achieve 90% with a lesser dose also then happy days.....

Even if it had a reliability of 60% it would still be good enough to make everything go back to normal. The two vaccines coming out with the 90%+ made everyone go a bit mad I think. Of course it'll be better if the different doses do give it a better efficiency but as long as it is safe and over 50% efficiency I'm sure it'll get approved at least in the UK and EU.

[J R Hartley]

Re: Coronavirus update

DRAKEFORD OUT!!!!

[Welshcake.]

Re: Coronavirus update

Even if it had a reliability of 60% it would still be good enough to make everything go back to normal. The two vaccines coming out with the 90%+ made everyone go a bit mad I think. Of course it'll be better if the different doses do give it a better efficiency but as long as it is safe and over 50% efficiency I'm sure it'll get approved at least in the UK and EU.

Most people seem to be overlooking that even 62% efficacy means that 62% will have immunity to Covid and the remaining 38% will have a milder disease.

None of the people vaccinated in the trails required hospital treatment.

Also something that really annoys me is the comparison to the flu jab. The reason the flu jab is 60% effective is that they predict which multiple strains of flu will be prevalent that year and adjust the jab accordingly. The Covid vaccine is targeting one single strain.

[goats]

Re: Coronavirus update

Most people seem to be overlooking that even 62% efficacy means that 62% will have immunity to Covid and the remaining 38% will have a milder disease.

None of the people vaccinated in the trails required hospital treatment.

Also something that really annoys me is the comparison to the flu jab. The reason the flu jab is 60% effective is that they predict which multiple strains of flu will be prevalent that year and adjust the jab accordingly. The Covid vaccine is targeting one single strain.

Good points

[goats]

Re: Coronavirus update

DRAKEFORD OUT!!!!

What’s he done now? Have I got to buy a meal now when I go to the pub?