Coronavirus update - NO MORE RESTRICTIONS

[lisvaneblue]

Re: Coronavirus update

https://www.bbc.co.uk/news/uk-politics-55410349

Ooooh has our Tony got a point.

Ex-Prime Minister Tony Blair is urging the government to give as many people as possible an initial dose of a Covid vaccine - rather than preserving stocks so there is enough for second jabs.

Good old Tony. Perhaps he's forgotten that the license as issued by the MHRA is for use of the vaccine as proven in trials ie two doses at regulated interval between first and final dose. To use as he suggested would probably be 'off license use' therefore the person authorising would be responsible for any problems occurring.

Surprised that a lawyer would make such off the cuff comments. There again there was a rumour that he talked up that Saddam had enough firepower to make him threat to our security.

[lisvaneblue]

Re: Coronavirus update

Tier 1 moving to 2 and more in Tier 4 in England.

Im glad Drakeford put us all in Tier 4.

May not be popular where its lower but this is spreading fast

Perhaps not everyone agreesC64CBDF8-DB5E-4971-90E8-61C3CFC47362.jpg

[cyril evans awaydays]

Re: Coronavirus update

Good old Tony. Perhaps he's forgotten that the license as issued by the MHRA is for use of the vaccine as proven in trials ie two doses at regulated interval between first and final dose. To use as he suggested would probably be 'off license use' therefore the person authorising would be responsible for any problems occurring.

Surprised that a lawyer would make such off the cuff comments. There again there was a rumour that he talked up that Saddam had enough firepower to make him threat to our security.

I am sure that there could be a number of reasons why Blair's idea would fall foul of practical reasons and MHRA processes. Surely WMD wouldn't be one of them though unless you were, what's the phrase, "playing with politics" of course.

[Tuerto]

Re: Coronavirus update

I am sure that there could be a number of reasons why Blair's idea would fall foul of practical reasons and MHRA processes. Surely WMD wouldn't be one of them though unless you were, what's the phrase, "playing with politics" of course.

Oh, go on then, The Tories supported the Invasion as well.

[xsnaggle]

Re: Coronavirus update

Oh, go on then, The Tories supported the Invasion as well.

Had to bite, didn't ya?

[Tuerto]

Re: Coronavirus update

Had to bite, didn't ya?

Yup.

[xsnaggle]

Re: Coronavirus update

Yup.

you mustn't let them do it to you.

[Tuerto]

Re: Coronavirus update

you mustn't let them do it to you.

i do it to myself

[cyril evans awaydays]

Re: Coronavirus update

Yup.

Look Lisvane Blue rubbished the idea on its origin not its merits. I don't know whether it's crazy to give part immunisation to lots more people than almost total immunisation in two doses to fewer people to get a better quicker result. What I do know is that because its author screwed up as a politician by supporting a ridiculous US Neo-Con agenda doesn't make it stupid. The re-appraisal of the vaccines in a single dose is obviously a factor but it will probably fail on the "not invented here principle".

[Tuerto]

Re: Coronavirus update

Look Lisvane Blue rubbished the idea on its origin not its merits. I don't know whether it's crazy to give part immunisation to lots more people than almost total immunisation in two doses to fewer people to get a better quicker result. What I do know is that because its author screwed up as a politician by supporting a ridiculous US Neo-Con agenda doesn't make it stupid. The re-appraisal of the vaccines in a single dose is obviously a factor but it will probably fail on the "not invented here principle".

Who knows, i'd be interested to know what scientific evidence Blair has to back up his claim. How effective and for how long would one shot be? And how soon after would people need the second shot, or would that go back to being the first shot, as the one before had expired. So many questions..

[cyril evans awaydays]

Re: Coronavirus update

Who knows, i'd be interested to know what scientific evidence Blair has to back up his claim. How effective and for how long would one shot be? And how soon after would people need the second shot, or would that go back to being the first shot, as the one before had expired. So many questions..

The basis of it seems to be that the current vaccines get a lower infection rate quicker by a single dose but it needs to be ready to make it work. The idea that competing commercial entities will be happy to engineer the optimal outcome for people once they have approved vaccines for commercial use is for the fairies!

[City123]

Re: Coronavirus update

Who knows, i'd be interested to know what scientific evidence Blair has to back up his claim. How effective and for how long would one shot be? And how soon after would people need the second shot, or would that go back to being the first shot, as the one before had expired. So many questions..

There was a doctor on the BBC making the point that the initial dose gave the most protection (51%) so it would be better to give more people the initial dose now

Whether or not that'll work or if its a good idea, I have no clue

[life on mars]

Re: Coronavirus update

Who knows, i'd be interested to know what scientific evidence Blair has to back up his claim. How effective and for how long would one shot be? And how soon after would people need the second shot, or would that go back to being the first shot, as the one before had expired. So many questions..

The theory has some support from the world of health see below however it comes with a caveat at the end :

"""His proposal was backed up by Professor David Salisbury, the man in charge of immunisation at the Department of Health until 2013.

He told Today the numbers were "straightforward".

"You give one dose you get 91% [protection] you give two doses and you get 95% - you are only gaining 4% for giving the second dose," he said.

"With current circumstances, I would strongly urge you to use as many first doses as you possibly can for risk groups and only after you have done all of that come back with second doses."

However, he acknowledged this would be harder to do with the Oxford University vaccine, where the efficacy of two doses is 60%.""

[lisvaneblue]

Re: Coronavirus update

The theory has some support from the world of health see below however it comes with a caveat at the end :

"""His proposal was backed up by Professor David Salisbury, the man in charge of immunisation at the Department of Health until 2013.

He told Today the numbers were "straightforward".

"You give one dose you get 91% [protection] you give two doses and you get 95% - you are only gaining 4% for giving the second dose," he said.

"With current circumstances, I would strongly urge you to use as many first doses as you possibly can for risk groups and only after you have done all of that come back with second doses."

However, he acknowledged this would be harder to do with the Oxford University vaccine, where the efficacy of two doses is 60%.""

It's all very well for people who've not got direct responsibility to make comments, but in the UK then only people with all the data are Pfizer and the MHRA. The go ahead for a two dose schedule was given by the MHRA and that is the licensed product.
If there is merit in one dose then MHRA would have to approve it otherwise it would be deemed unlicensed use of the product, and should anything go wrong Pfizer would have no responsibility. Indeed the responsibility for use of an unlicensed product usually rests with the prescriber, and such should only be used when there is no clinical alternative.

When you weigh up the length of time it might take to get approval for a one dose vaccine when all those in the pipeline seems to be based on two dose regime anyhow, then it does not seem a practical alternative for what is a short term problem.

Currently Wales share of the Pfizer vaccine alone is enough to cover 1m of the population with two doses. ( ie 5% of 40m doses) Currently the problem is that we are only giving 12,000 injections a week in Wales and unless that steps up rapidly, with second injections needed soon for the groups who have had their first, we are only protecting 6,000 people a week